The DNA damage response

The G2-M DNA damage checkpoint is an important cell cycle checkpoint in eukaryotic organisms that ensures that cells don't initiate mitosis until damaged or ...

由 HL Smith 著作 · 2020 · 被引用 202 次 — Loss of G1 checkpoint control is common in cancer through TP53, ATM mutations, Rb loss or cyclin E overexpression, providing a stronger ...

由 P Pizzul 著作 · 2022 · 被引用 23 次 — In budding yeast, a single unrepairable DSB is sufficient to induce a strong checkpoint activation that persist approximately a dozen hours, after which cells ...

由 BBS Zhou 著作 · 2000 · 被引用 4288 次 — DNA damage checkpoints were initially defined as non-essential regulatory pathways that control the ability of cells to arrest the cell cycle in ...

由 VG Gorgoulis 著作 · 2005 · 被引用 2406 次 — DNA damage checkpoint genes, such as p53, are frequently mutated in human cancer, but the selective pressure for their inactivation remains ...

由 CQX Yam 著作 · 2022 · 被引用 15 次 — Here, we discuss the DNA damage checkpoint, the mitotic networks it inhibits to prevent segregation of damaged chromosomes and the strategies ...

The DNA damage checkpoint provides the cell with an opportunity to stall cell division such that an effective DNA repair effort can be mounted.